Hispana. Acceso en línea al Patrimonio Cultural Digital Español

Está en:  › Dades de registre

α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach

Identificadores del recurso

Mini-Reviews in Medicinal Chemistry 9.12 (2009): 1389-1396

1389-5575 (print)

1875-5607 (online)

http://hdl.handle.net/10486/665374

10.2174/138955709789957422

1389

1396

Procedència

(Biblos-e Archivo)

Fitxa

Títol:: α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach
Tema:: α-N-heterocyclic thiosemicarbazone; Antitumour agents; Bis(thiosemicarbazone); Metal complexes; Ribonucleotide reductase inhibitors; Structure-activity relationships; Química
Descripció:: α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships; The authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain
Idioma:: English
Autor/Productor:: Matesanz García, Ana Isabel; Souza, Pilar
Editor:: Bentham Science Publishers
Otros colaboradores/productores:: UAM. Departamento de Química Inorgánica
Drets:: open access
Data:: 2009-12-01
Tipo de recurso:: journal article; info:eu-repo/semantics/acceptedVersion
Format:: application/pdf

oai_dc

Descarregar XML

<?xml version="1.0" encoding="UTF-8" ?>

<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
1. <dc:title>α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach</dc:title>
2. <dc:creator>Matesanz García, Ana Isabel</dc:creator>
3. <dc:creator>Souza, Pilar</dc:creator>
4. <dc:contributor>UAM. Departamento de Química Inorgánica</dc:contributor>
5. <dc:subject>α-N-heterocyclic thiosemicarbazone</dc:subject>
6. <dc:subject>Antitumour agents</dc:subject>
7. <dc:subject>Bis(thiosemicarbazone)</dc:subject>
8. <dc:subject>Metal complexes</dc:subject>
9. <dc:subject>Ribonucleotide reductase inhibitors</dc:subject>
10. <dc:subject>Structure-activity relationships</dc:subject>
11. <dc:subject>Química</dc:subject>
12. <dc:description>α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships</dc:description>
13. <dc:description>The authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain</dc:description>
14. <dc:date>2009-12-01</dc:date>
15. <dc:type>journal article</dc:type>
16. <dc:type>info:eu-repo/semantics/acceptedVersion</dc:type>
17. <dc:identifier>Mini-Reviews in Medicinal Chemistry 9.12 (2009): 1389-1396</dc:identifier>
18. <dc:identifier>1389-5575 (print)</dc:identifier>
19. <dc:identifier>1875-5607 (online)</dc:identifier>
20. <dc:identifier>http://hdl.handle.net/10486/665374</dc:identifier>
21. <dc:identifier>10.2174/138955709789957422</dc:identifier>
22. <dc:identifier>1389</dc:identifier>
23. <dc:identifier>12</dc:identifier>
24. <dc:identifier>1396</dc:identifier>
25. <dc:identifier>9</dc:identifier>
26. <dc:language>eng</dc:language>
27. <dc:rights>open access</dc:rights>
28. <dc:format>application/pdf</dc:format>
29. <dc:publisher>Bentham Science Publishers</dc:publisher>
</oai_dc:dc>

oai_openaire

Descarregar XML

<?xml version="1.0" encoding="UTF-8" ?>

<oaire:resource schemaLocation="http://namespace.openaire.eu/schema/oaire/ https://www.openaire.eu/schema/repo-lit/4.0/openaire.xsd">
1. <datacite:titles>
  1. <datacite:title>α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach</datacite:title>
  </datacite:titles>
2. <datacite:creators>
  1. <datacite:creator>
    1. <datacite:creatorName>Matesanz García, Ana Isabel</datacite:creatorName>
    2. <datacite:nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org">0000-0002-6113-0656</datacite:nameIdentifier>
    3. <datacite:affiliation>Universidad Autónoma de Madrid</datacite:affiliation>
    </datacite:creator>
  2. <datacite:creator>
    1. <datacite:creatorName>Souza, Pilar</datacite:creatorName>
    </datacite:creator>
  </datacite:creators>
3. <datacite:contributors>
  1. <datacite:contributor contributorType="Other">
    1. <datacite:contributorName>UAM. Departamento de Química Inorgánica</datacite:contributorName>
    </datacite:contributor>
  </datacite:contributors>
4. <datacite:subjects>
  1. <datacite:subject>α-N-heterocyclic thiosemicarbazone</datacite:subject>
  2. <datacite:subject>Antitumour agents</datacite:subject>
  3. <datacite:subject>Bis(thiosemicarbazone)</datacite:subject>
  4. <datacite:subject>Metal complexes</datacite:subject>
  5. <datacite:subject>Ribonucleotide reductase inhibitors</datacite:subject>
  6. <datacite:subject>Structure-activity relationships</datacite:subject>
  7. <datacite:subject>Química</datacite:subject>
  </datacite:subjects>
5. <dc:description>α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships</dc:description>
6. <dc:description>The authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain</dc:description>
7. <datacite:dates>
  1. <datacite:date dateType="Issued">2009-12-01</datacite:date>
  </datacite:dates>
8. <oaire:resourceType resourceTypeGeneral="literature" uri="http://purl.org/coar/resource_type/c_6501">journal article</oaire:resourceType>
9. <oaire:version uri="http://purl.org/coar/version/c_be7fb7dd8ff6fe43">NA</oaire:version>
10. <datacite:identifier identifierType="HANDLE">http://hdl.handle.net/10486/665374</datacite:identifier>
11. <datacite:alternateIdentifiers>
  1. <datacite:alternateIdentifier alternateIdentifierType="DOI">10.2174/138955709789957422</datacite:alternateIdentifier>
  </datacite:alternateIdentifiers>
12. <datacite:relatedIdentifiers>
  1. <datacite:relatedIdentifier relatedIdentifierType="ISSN" relationType="IsPartOf">1389-5575 (print)</datacite:relatedIdentifier>
  2. <datacite:relatedIdentifier relatedIdentifierType="ISSN" relationType="IsPartOf">1875-5607 (online)</datacite:relatedIdentifier>
  </datacite:relatedIdentifiers>
13. <dc:language>eng</dc:language>
14. <datacite:rights rightsURI="http://purl.org/coar/access_right/c_abf2">open access</datacite:rights>
15. <dc:format>application/pdf</dc:format>
16. <datacite:sizes>
  1. <datacite:size>8 pag.</datacite:size>
  </datacite:sizes>
17. <dc:publisher>Bentham Science Publishers</dc:publisher>
18. <oaire:file objectType="fulltext">https://repositorio.uam.es/bitstream/10486/665374/1/heterocyclic_matesanz_mrmc_2009_ps.pdf</oaire:file>
</oaire:resource>

xoai

Descarregar XML

<?xml version="1.0" encoding="UTF-8" ?>

<metadata schemaLocation="http://www.lyncode.com/xoai http://www.lyncode.com/xsd/xoai.xsd">
1. <element name="dc">
  1. <element name="contributor">
    1. <element name="author">
      1. <element name="none">
        <field name="value">Matesanz García, Ana Isabel</field>
        <field name="authority">258554</field>
        <field name="confidence">500</field>
        <field name="orcid_id">0000-0002-6113-0656</field>
        <field name="value">Souza, Pilar</field>
        <field name="authority">1c91971f-3a26-4907-a92f-820aa4b32a84</field>
        <field name="confidence">500</field>
        <field name="orcid_id" />
        </element>
      </element>
    2. <element name="other">
      1. <element name="es_ES">
        <field name="value">UAM. Departamento de Química Inorgánica</field>
        </element>
      </element>
    </element>
  2. <element name="date">
    1. <element name="issued">
      1. <element name="none">
        <field name="value">2009-12-01</field>
        </element>
      </element>
    </element>
  3. <element name="identifier">
    1. <element name="citation">
      1. <element name="en_US">
        <field name="value">Mini-Reviews in Medicinal Chemistry 9.12 (2009): 1389-1396</field>
        </element>
      </element>
    2. <element name="issn">
      1. <element name="es_ES">
        <field name="value">1389-5575 (print)</field>
        <field name="value">1875-5607 (online)</field>
        </element>
      </element>
    3. <element name="uri">
      1. <element name="none">
        <field name="value">http://hdl.handle.net/10486/665374</field>
        </element>
      </element>
    4. <element name="doi">
      1. <element name="es_ES">
        <field name="value">10.2174/138955709789957422</field>
        </element>
      </element>
    5. <element name="publicationfirstpage">
      1. <element name="es_ES">
        <field name="value">1389</field>
        </element>
      </element>
    6. <element name="publicationissue">
      1. <element name="es_ES">
        <field name="value">12</field>
        </element>
      </element>
    7. <element name="publicationlastpage">
      1. <element name="es_ES">
        <field name="value">1396</field>
        </element>
      </element>
    8. <element name="publicationvolume">
      1. <element name="es_ES">
        <field name="value">9</field>
        </element>
      </element>
    </element>
  4. <element name="description">
    1. <element name="abstract">
      1. <element name="en_US">
        <field name="value">α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships</field>
        </element>
      </element>
    2. <element name="sponsorship">
      1. <element name="en_US">
        <field name="value">The authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain</field>
        </element>
      </element>
    </element>
  5. <element name="format">
    1. <element name="extent">
      1. <element name="en">
        <field name="value">8 pag.</field>
        </element>
      </element>
    2. <element name="mimetype">
      1. <element name="en">
        <field name="value">application/pdf</field>
        </element>
      </element>
    </element>
  6. <element name="language">
    1. <element name="iso">
      1. <element name="en">
        <field name="value">eng</field>
        </element>
      </element>
    </element>
  7. <element name="publisher">
    1. <element name="en_US">
      1. <field name="value">Bentham Science Publishers</field>
      </element>
    </element>
  8. <element name="relation" />
  9. <element name="rights">
    1. <element name="accessRights">
      1. <element name="en">
        <field name="value">open access</field>
        </element>
      </element>
    </element>
  10. <element name="subject">
    1. <element name="other">
      1. <element name="en_US">
        <field name="value">α-N-heterocyclic thiosemicarbazone</field>
        <field name="value">Antitumour agents</field>
        <field name="value">Bis(thiosemicarbazone)</field>
        <field name="value">Metal complexes</field>
        <field name="value">Ribonucleotide reductase inhibitors</field>
        <field name="value">Structure-activity relationships</field>
        </element>
      </element>
    2. <element name="eciencia">
      1. <element name="es_ES">
        <field name="value">Química</field>
        </element>
      </element>
    </element>
  11. <element name="title">
    1. <element name="en_US">
      1. <field name="value">α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach</field>
      </element>
    </element>
  12. <element name="type">
    1. <element name="en">
      1. <field name="value">journal article</field>
      </element>
    2. <element name="version">
      1. <element name="en">
        <field name="value">info:eu-repo/semantics/acceptedVersion</field>
        </element>
      </element>
    </element>
  13. <element name="facultadUAM">
    1. <element name="none">
      1. <field name="value">Facultad de Ciencias</field>
      </element>
    </element>
  </element>
2. <element name="bundles">
  1. <element name="bundle">
    1. <field name="name">THUMBNAIL</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">heterocyclic_matesanz_mrmc_2009_ps.pdf.jpg</field>
        <field name="originalName">heterocyclic_matesanz_mrmc_2009_ps.pdf.jpg</field>
        <field name="description">Generated Thumbnail</field>
        <field name="format">image/jpeg</field>
        <field name="size">1157</field>
        <field name="url">https://repositorio.uam.es/bitstream/10486/665374/3/heterocyclic_matesanz_mrmc_2009_ps.pdf.jpg</field>
        <field name="checksum">b07c3e0ba5660e58474997930e79c5c6</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">3</field>
        </element>
      </element>
    </element>
  2. <element name="bundle">
    1. <field name="name">ORIGINAL</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">heterocyclic_matesanz_mrmc_2009_ps.pdf</field>
        <field name="originalName">heterocyclic_matesanz_mrmc_2009_ps.pdf</field>
        <field name="format">application/pdf</field>
        <field name="size">506638</field>
        <field name="url">https://repositorio.uam.es/bitstream/10486/665374/1/heterocyclic_matesanz_mrmc_2009_ps.pdf</field>
        <field name="checksum">f99141f65a25c0e98d564bfa4c728ce0</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">1</field>
        </element>
      </element>
    </element>
  3. <element name="bundle">
    1. <field name="name">LICENSE</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">license.txt</field>
        <field name="originalName">license.txt</field>
        <field name="format">text/plain; charset=utf-8</field>
        <field name="size">4105</field>
        <field name="url">https://repositorio.uam.es/bitstream/10486/665374/2/license.txt</field>
        <field name="checksum">c9c6ba57a9a0757a94b73bd12b549d9f</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">2</field>
        </element>
      </element>
    </element>
  4. <element name="bundle">
    1. <field name="name">TEXT</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">heterocyclic_matesanz_mrmc_2009_ps.pdf.txt</field>
        <field name="originalName">heterocyclic_matesanz_mrmc_2009_ps.pdf.txt</field>
        <field name="description">Extracted text</field>
        <field name="format">text/plain</field>
        <field name="size">43916</field>
        <field name="url">https://repositorio.uam.es/bitstream/10486/665374/4/heterocyclic_matesanz_mrmc_2009_ps.pdf.txt</field>
        <field name="checksum">95c4ab149fb4da6afc31b1d04a9a51e7</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">4</field>
        </element>
      </element>
    </element>
  </element>
3. <element name="others">
  1. <field name="handle">10486/665374</field>
  2. <field name="identifier">oai:repositorio.uam.es:10486/665374</field>
  3. <field name="lastModifyDate">2022-05-05 09:43:55.941</field>
  </element>
4. <element name="repository">
  1. <field name="name">Universidad Autónoma de Madrid</field>
  2. <field name="mail">biblosearchivo.biblioteca@uam.es</field>
  </element>
5. <element name="license">
  1. <field name="bin">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</field>
  </element>
</metadata>