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β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis

Identificadores del recurso

Molecular Medicine Report. 2018 Jun;17(6):7987-7995

1791-3004

1791-2997

https://hdl.handle.net/11000/32325

Procedencia

(Repositorio Institucional REDIUMH)

Ficha

Título:: β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis
Tema:: β2 adrenoceptors; liver cirrhosis; osteoarthritis; polymorphisms; isoproterenol; cAMP
Descrición:: The present study was designed to investigate the functional status of β2 adrenoceptors (β2AR) in two models of chronic inflammatory disease: liver cirrhosis (LC) and osteoarthritis (OA). The β2AR gene contains three single nucleotide polymorphisms at amino acid positions 16, 27 and 164. The aim of the present study was to investigate the potential influence of lymphocyte β2AR receptor functionality and genotype in LC and OA patients. Blood samples from cirrhotic patients (n=52, hepatic venous pressure gradient 13±4 mmHg, CHILD 7±2 and MELD 11±4 scores), OA patients (n=30, 84% Kellgren‑Lawrence severity 4 grade, 14% knee replacement joint) and healthy volunteers as control group (n=26) were analyzed. Peripheral blood mononuclear cells (PBMC) were isolated from whole blood and basal and isoproterenol induced adenylate cyclase activity (isoproterenol stimulus from 10‑9 to 10‑4 mM), and β2AR allelic variants (rs1042713, rs1042714, rs1800888) were determined. β2AR functionality was decreased in the two different models of chronic inflammatory disease studied, OA (50% vs. control) and LC (85% vs. control). In these patients, the strength of the β2AR response to adrenergic stimulation was very limited. Adrenergic modulation of PBMC function through the β2AR stimulus is decreased in chronic inflammatory processes including LC and OA, suggesting that the adrenergic system may be important in the development of these processes.
Idioma:: English
Relación:: https://doi.org/10.3892/mmr.2018.8820
Autor/Productor:: ROCA, REYES; ESTEBAN, PABLO; Zapater, Pedro; Inda, María del Mar; CONTE, LUCIA; Gómez-Escolar, Laura; MARTÍNEZ, HELENA; Horga, José Francisco; PALAZON, JOSÉ M.; Peiró, Ana
Editor:: Spandidos publications
Otros colaboradores/productores:: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Dereitos:: info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by-nc-nd/4.0/
Data:: 2024-06-20T10:46:53Z; 2018-06
Tipo de recurso:: info:eu-repo/semantics/article
Formato:: application/pdf; 9

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</metadata>