Hispana. Acceso en línea al Patrimonio Cultural Digital Español

Está en:  › Erregistro

'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'

Identificadores del recurso

1662-4548

10.3389/fnins.2020.00107

https://academica-e.unavarra.es/handle/2454/37302

Jatorria

(Academica-e: repositorio digital de la Universidad Pública de Navarra)

Fitxa

Izenburu:: 'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'
Tema:: Circadian; Peripheral clocks; Transcription factor; Light-dark cycles; Autonomous
Deskribapen:: These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).; This work was supported by The Spanish Ministry of Science, Innovation and Universities (Ramón y Cajal programme: RYC-2018-023874-I).
Idioma:: English
Harreman:: Frontiers in Neuroscience, 2020, 14, 107; https://doi.org/10.3389/fnins.2020.00107
Autor/Productor:: Rotinen Díaz, Mirja Sofia
Argitaratzaile:: Frontiers Media
Otros colaboradores/productores:: Ciencias de la Salud; Osasun Zientziak
Eskubideak:: © 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.; info:eu-repo/semantics/openAccess
Data:: 2020
Tipo de recurso:: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Versión publicada / Argitaratu den bertsioa
Formatu:: 3 p.; application/pdf

oai_dc

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
1. <dc:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</dc:title>
2. <dc:creator>Rotinen Díaz, Mirja Sofia</dc:creator>
3. <dc:contributor>Ciencias de la Salud</dc:contributor>
4. <dc:contributor>Osasun Zientziak</dc:contributor>
5. <dc:subject>Circadian</dc:subject>
6. <dc:subject>Peripheral clocks</dc:subject>
7. <dc:subject>Transcription factor</dc:subject>
8. <dc:subject>Light-dark cycles</dc:subject>
9. <dc:subject>Autonomous</dc:subject>
10. <dc:description>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</dc:description>
11. <dc:description>This work was supported by The Spanish Ministry of Science, Innovation and Universities (Ramón y Cajal programme: RYC-2018-023874-I).</dc:description>
12. <dc:date>2020</dc:date>
13. <dc:type>info:eu-repo/semantics/article</dc:type>
14. <dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
15. <dc:type>Versión publicada / Argitaratu den bertsioa</dc:type>
16. <dc:identifier>1662-4548</dc:identifier>
17. <dc:identifier>10.3389/fnins.2020.00107</dc:identifier>
18. <dc:identifier>https://academica-e.unavarra.es/handle/2454/37302</dc:identifier>
19. <dc:language>eng</dc:language>
20. <dc:relation>Frontiers in Neuroscience, 2020, 14, 107</dc:relation>
21. <dc:relation>https://doi.org/10.3389/fnins.2020.00107</dc:relation>
22. <dc:rights>© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</dc:rights>
23. <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
24. <dc:format>3 p.</dc:format>
25. <dc:format>application/pdf</dc:format>
26. <dc:format>application/pdf</dc:format>
27. <dc:publisher>Frontiers Media</dc:publisher>
</oai_dc:dc>

didl

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<d:DIDL schemaLocation="urn:mpeg:mpeg21:2002:02-DIDL-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/did/didl.xsd">
1. <d:Item id="hdl_2454_37302">
  1. <d:Descriptor>
    1. <d:Statement mimeType="application/xml; charset=utf-8">
      1. <dii:Identifier schemaLocation="urn:mpeg:mpeg21:2002:01-DII-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/dii/dii.xsd">urn:hdl:2454/37302</dii:Identifier>
      </d:Statement>
    </d:Descriptor>
  2. <d:Descriptor>
    1. <d:Statement mimeType="application/xml; charset=utf-8">
      1. <oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
        <dc:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</dc:title>
        <dc:creator>Rotinen Díaz, Mirja Sofia</dc:creator>
        <dc:contributor>Ciencias de la Salud</dc:contributor>
        <dc:contributor>Osasun Zientziak</dc:contributor>
        <dc:subject>Circadian</dc:subject>
        <dc:subject>Peripheral clocks</dc:subject>
        <dc:subject>Transcription factor</dc:subject>
        <dc:subject>Light-dark cycles</dc:subject>
        <dc:subject>Autonomous</dc:subject>
        <dc:description>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</dc:description>
        <dc:date>2020</dc:date>
        <dc:type>info:eu-repo/semantics/article</dc:type>
        <dc:identifier>1662-4548</dc:identifier>
        <dc:identifier>10.3389/fnins.2020.00107</dc:identifier>
        <dc:identifier>https://academica-e.unavarra.es/handle/2454/37302</dc:identifier>
        <dc:language>eng</dc:language>
        <dc:relation>Frontiers in Neuroscience, 2020, 14, 107</dc:relation>
        <dc:relation>https://doi.org/10.3389/fnins.2020.00107</dc:relation>
        <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
        <dc:rights>© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</dc:rights>
        <dc:publisher>Frontiers Media</dc:publisher>
        </oai_dc:dc>
      </d:Statement>
    </d:Descriptor>
  3. <d:Component id="2454_37302_1">
    1. <d:Resource mimeType="application/pdf" ref="https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download" />
    </d:Component>
  </d:Item>
</d:DIDL>

dim

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<dim:dim schemaLocation="http://www.dspace.org/xmlns/dspace/dim http://www.dspace.org/schema/dim.xsd">
1. <dim:field element="entity" mdschema="dspace" qualifier="type">Publication</dim:field>
2. <dim:field authority="virtual::14186" confidence="-1" element="contributor" mdschema="dc" qualifier="author">Rotinen Díaz, Mirja Sofia</dim:field>
3. <dim:field element="contributor" lang="es_ES" mdschema="dc" qualifier="department">Ciencias de la Salud</dim:field>
4. <dim:field element="contributor" lang="eu" mdschema="dc" qualifier="department">Osasun Zientziak</dim:field>
5. <dim:field element="date" mdschema="dc" qualifier="issued">2020</dim:field>
6. <dim:field element="identifier" mdschema="dc" qualifier="issn">1662-4548</dim:field>
7. <dim:field element="identifier" mdschema="dc" qualifier="doi">10.3389/fnins.2020.00107</dim:field>
8. <dim:field element="identifier" mdschema="dc" qualifier="uri">https://academica-e.unavarra.es/handle/2454/37302</dim:field>
9. <dim:field element="description" lang="en" mdschema="dc" qualifier="abstract">These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</dim:field>
10. <dim:field element="description" lang="en" mdschema="dc" qualifier="sponsorship">This work was supported by The Spanish Ministry of Science, Innovation and Universities (Ramón y Cajal programme: RYC-2018-023874-I).</dim:field>
11. <dim:field element="format" mdschema="dc" qualifier="extent">3 p.</dim:field>
12. <dim:field element="format" lang="en" mdschema="dc" qualifier="mimetype">application/pdf</dim:field>
13. <dim:field element="language" lang="en" mdschema="dc" qualifier="iso">eng</dim:field>
14. <dim:field element="publisher" lang="en" mdschema="dc">Frontiers Media</dim:field>
15. <dim:field element="relation" lang="en" mdschema="dc" qualifier="ispartof">Frontiers in Neuroscience, 2020, 14, 107</dim:field>
16. <dim:field element="relation" mdschema="dc" qualifier="publisherversion">https://doi.org/10.3389/fnins.2020.00107</dim:field>
17. <dim:field element="rights" lang="en" mdschema="dc">© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</dim:field>
18. <dim:field element="rights" mdschema="dc" qualifier="accessRights">info:eu-repo/semantics/openAccess</dim:field>
19. <dim:field element="subject" lang="en" mdschema="dc">Circadian</dim:field>
20. <dim:field element="subject" lang="en" mdschema="dc">Peripheral clocks</dim:field>
21. <dim:field element="subject" lang="en" mdschema="dc">Transcription factor</dim:field>
22. <dim:field element="subject" lang="en" mdschema="dc">Light-dark cycles</dim:field>
23. <dim:field element="subject" lang="en" mdschema="dc">Autonomous</dim:field>
24. <dim:field element="title" lang="en" mdschema="dc">'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</dim:field>
25. <dim:field element="type" mdschema="dc">info:eu-repo/semantics/article</dim:field>
26. <dim:field element="type" lang="en" mdschema="dc" qualifier="version">info:eu-repo/semantics/publishedVersion</dim:field>
27. <dim:field element="type" lang="es" mdschema="dc" qualifier="version">Versión publicada / Argitaratu den bertsioa</dim:field>
28. <dim:field authority="virtual::14186" confidence="-1" element="isAuthorOfPublication" mdschema="relation">ecbb6fbe-3bda-4cad-945f-f263c1af5981</dim:field>
29. <dim:field authority="virtual::14186" confidence="-1" element="isAuthorOfPublication" mdschema="relation" qualifier="latestForDiscovery">ecbb6fbe-3bda-4cad-945f-f263c1af5981</dim:field>
</dim:dim>

etdms

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<thesis schemaLocation="http://www.ndltd.org/standards/metadata/etdms/1.0/ http://www.ndltd.org/standards/metadata/etdms/1.0/etdms.xsd">
1. <title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</title>
2. <creator>Rotinen Díaz, Mirja Sofia</creator>
3. <contributor>Ciencias de la Salud</contributor>
4. <contributor>Osasun Zientziak</contributor>
5. <subject>Circadian</subject>
6. <subject>Peripheral clocks</subject>
7. <subject>Transcription factor</subject>
8. <subject>Light-dark cycles</subject>
9. <subject>Autonomous</subject>
10. <description>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</description>
11. <date>2020</date>
12. <type>info:eu-repo/semantics/article</type>
13. <identifier>1662-4548</identifier>
14. <identifier>10.3389/fnins.2020.00107</identifier>
15. <identifier>https://academica-e.unavarra.es/handle/2454/37302</identifier>
16. <language>eng</language>
17. <relation>Frontiers in Neuroscience, 2020, 14, 107</relation>
18. <relation>https://doi.org/10.3389/fnins.2020.00107</relation>
19. <rights>info:eu-repo/semantics/openAccess</rights>
20. <rights>© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</rights>
21. <publisher>Frontiers Media</publisher>
</thesis>

marc

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<record schemaLocation="http://www.loc.gov/MARC21/slim http://www.loc.gov/standards/marcxml/schema/MARC21slim.xsd">
1. <leader>00925njm 22002777a 4500</leader>
2. <datafield ind1=" " ind2=" " tag="042">
  1. <subfield code="a">dc</subfield>
  </datafield>
3. <datafield ind1=" " ind2=" " tag="720">
  1. <subfield code="a">Rotinen Díaz, Mirja Sofia</subfield>
  2. <subfield code="e">author</subfield>
  </datafield>
4. <datafield ind1=" " ind2=" " tag="260">
  1. <subfield code="c">2020</subfield>
  </datafield>
5. <datafield ind1=" " ind2=" " tag="520">
  1. <subfield code="a">These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</subfield>
  </datafield>
6. <datafield ind1="8" ind2=" " tag="024">
  1. <subfield code="a">1662-4548</subfield>
  </datafield>
7. <datafield ind1="8" ind2=" " tag="024">
  1. <subfield code="a">10.3389/fnins.2020.00107</subfield>
  </datafield>
8. <datafield ind1="8" ind2=" " tag="024">
  1. <subfield code="a">https://academica-e.unavarra.es/handle/2454/37302</subfield>
  </datafield>
9. <datafield ind1=" " ind2=" " tag="653">
  1. <subfield code="a">Circadian</subfield>
  </datafield>
10. <datafield ind1=" " ind2=" " tag="653">
  1. <subfield code="a">Peripheral clocks</subfield>
  </datafield>
11. <datafield ind1=" " ind2=" " tag="653">
  1. <subfield code="a">Transcription factor</subfield>
  </datafield>
12. <datafield ind1=" " ind2=" " tag="653">
  1. <subfield code="a">Light-dark cycles</subfield>
  </datafield>
13. <datafield ind1=" " ind2=" " tag="653">
  1. <subfield code="a">Autonomous</subfield>
  </datafield>
14. <datafield ind1="0" ind2="0" tag="245">
  1. <subfield code="a">'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</subfield>
  </datafield>
</record>

mets

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<mets ID=" DSpace_ITEM_2454-37302" OBJID=" hdl:2454/37302" PROFILE="DSpace METS SIP Profile 1.0" TYPE="DSpace ITEM" schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd">
1. <metsHdr CREATEDATE="2025-03-05T03:50:46Z">
  1. <agent ROLE="CUSTODIAN" TYPE="ORGANIZATION">
    1. <name>Academica-e</name>
    </agent>
  </metsHdr>
2. <dmdSec ID="DMD_2454_37302">
  1. <mdWrap MDTYPE="MODS">
    1. <xmlData schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd">
      1. <mods:mods schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd">
        <mods:name>
        <mods:role>
        <mods:roleTerm type="text">author</mods:roleTerm>
        </mods:role>
        <mods:namePart>Rotinen Díaz, Mirja Sofia</mods:namePart>
        </mods:name>
        <mods:name>
        <mods:role>
        <mods:roleTerm type="text">department</mods:roleTerm>
        </mods:role>
        <mods:namePart>Ciencias de la Salud</mods:namePart>
        </mods:name>
        <mods:name>
        <mods:role>
        <mods:roleTerm type="text">department</mods:roleTerm>
        </mods:role>
        <mods:namePart>Osasun Zientziak</mods:namePart>
        </mods:name>
        <mods:originInfo>
        <mods:dateIssued encoding="iso8601">2020</mods:dateIssued>
        </mods:originInfo>
        <mods:identifier type="issn">1662-4548</mods:identifier>
        <mods:identifier type="doi">10.3389/fnins.2020.00107</mods:identifier>
        <mods:identifier type="uri">https://academica-e.unavarra.es/handle/2454/37302</mods:identifier>
        <mods:abstract>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</mods:abstract>
        <mods:language>
        <mods:languageTerm authority="rfc3066">eng</mods:languageTerm>
        </mods:language>
        <mods:accessCondition type="useAndReproduction">© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</mods:accessCondition>
        <mods:subject>
        <mods:topic>Circadian</mods:topic>
        </mods:subject>
        <mods:subject>
        <mods:topic>Peripheral clocks</mods:topic>
        </mods:subject>
        <mods:subject>
        <mods:topic>Transcription factor</mods:topic>
        </mods:subject>
        <mods:subject>
        <mods:topic>Light-dark cycles</mods:topic>
        </mods:subject>
        <mods:subject>
        <mods:topic>Autonomous</mods:topic>
        </mods:subject>
        <mods:titleInfo>
        <mods:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</mods:title>
        </mods:titleInfo>
        <mods:genre>info:eu-repo/semantics/article</mods:genre>
        </mods:mods>
      </xmlData>
    </mdWrap>
  </dmdSec>
3. <amdSec ID="TMD_2454_37302">
  1. <rightsMD ID="RIG_2454_37302">
    1. <mdWrap MDTYPE="OTHER" MIMETYPE="text/plain" OTHERMDTYPE="DSpaceDepositLicense">
      1. <binData>Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0IG93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLCB0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZyB0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sIGluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlIHN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yIHB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZSB0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQgdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uIGFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LCB5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZSBjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCBzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkIHdpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRCBCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUgRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSCBDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZSBzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMgbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=</binData>
      </mdWrap>
    </rightsMD>
  </amdSec>
4. <amdSec ID="FO_2454_37302_1">
  1. <techMD ID="TECH_O_2454_37302_1">
    1. <mdWrap MDTYPE="PREMIS">
      1. <xmlData schemaLocation="http://www.loc.gov/standards/premis http://www.loc.gov/standards/premis/PREMIS-v1-0.xsd">
        <premis:premis>
        <premis:object>
        <premis:objectIdentifier>
        <premis:objectIdentifierType>URL</premis:objectIdentifierType>
        <premis:objectIdentifierValue>https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download</premis:objectIdentifierValue>
        </premis:objectIdentifier>
        <premis:objectCategory>File</premis:objectCategory>
        <premis:objectCharacteristics>
        <premis:fixity>
        <premis:messageDigestAlgorithm>MD5</premis:messageDigestAlgorithm>
        <premis:messageDigest>f99aaa28b8bce5b6eb585dc19ed42d35</premis:messageDigest>
        </premis:fixity>
        <premis:size>363013</premis:size>
        <premis:format>
        <premis:formatDesignation>
        <premis:formatName>application/pdf</premis:formatName>
        </premis:formatDesignation>
        </premis:format>
        </premis:objectCharacteristics>
        <premis:originalName>2020060107_Rotinen_DefiningIndependence.pdf</premis:originalName>
        </premis:object>
        </premis:premis>
        </xmlData>
      </mdWrap>
    </techMD>
  </amdSec>
5. <amdSec ID="FT_2454_37302_2">
  1. <techMD ID="TECH_T_2454_37302_2">
    1. <mdWrap MDTYPE="PREMIS">
      1. <xmlData schemaLocation="http://www.loc.gov/standards/premis http://www.loc.gov/standards/premis/PREMIS-v1-0.xsd">
        <premis:premis>
        <premis:object>
        <premis:objectIdentifier>
        <premis:objectIdentifierType>URL</premis:objectIdentifierType>
        <premis:objectIdentifierValue>https://academica-e.unavarra.es/bitstreams/dd3a666b-e649-48ad-adf1-adf8ad28f915/download</premis:objectIdentifierValue>
        </premis:objectIdentifier>
        <premis:objectCategory>File</premis:objectCategory>
        <premis:objectCharacteristics>
        <premis:fixity>
        <premis:messageDigestAlgorithm>MD5</premis:messageDigestAlgorithm>
        <premis:messageDigest>c4a8a14519d97a7e1f69393ce3164d21</premis:messageDigest>
        </premis:fixity>
        <premis:size>12442</premis:size>
        <premis:format>
        <premis:formatDesignation>
        <premis:formatName>text/plain</premis:formatName>
        </premis:formatDesignation>
        </premis:format>
        </premis:objectCharacteristics>
        <premis:originalName>2020060107_Rotinen_DefiningIndependence.pdf.txt</premis:originalName>
        </premis:object>
        </premis:premis>
        </xmlData>
      </mdWrap>
    </techMD>
  </amdSec>
6. <fileSec>
  1. <fileGrp USE="ORIGINAL">
    1. <file ADMID="FO_2454_37302_1" CHECKSUM="f99aaa28b8bce5b6eb585dc19ed42d35" CHECKSUMTYPE="MD5" GROUPID="GROUP_BITSTREAM_2454_37302_1" ID="BITSTREAM_ORIGINAL_2454_37302_1" MIMETYPE="application/pdf" SEQ="1" SIZE="363013">
      1. <FLocat LOCTYPE="URL" href="https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download" type="simple" />
      </file>
    </fileGrp>
  2. <fileGrp USE="TEXT">
    1. <file ADMID="FT_2454_37302_2" CHECKSUM="c4a8a14519d97a7e1f69393ce3164d21" CHECKSUMTYPE="MD5" GROUPID="GROUP_BITSTREAM_2454_37302_2" ID="BITSTREAM_TEXT_2454_37302_2" MIMETYPE="text/plain" SEQ="2" SIZE="12442">
      1. <FLocat LOCTYPE="URL" href="https://academica-e.unavarra.es/bitstreams/dd3a666b-e649-48ad-adf1-adf8ad28f915/download" type="simple" />
      </file>
    </fileGrp>
  </fileSec>
7. <structMap LABEL="DSpace Object" TYPE="LOGICAL">
  1. <div ADMID="DMD_2454_37302" TYPE="DSpace Object Contents">
    1. <div TYPE="DSpace BITSTREAM">
      1. <fptr FILEID="BITSTREAM_ORIGINAL_2454_37302_1" />
      </div>
    </div>
  </structMap>
</mets>

mods

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<mods:mods schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd">
1. <mods:name>
  1. <mods:namePart>Rotinen Díaz, Mirja Sofia</mods:namePart>
  </mods:name>
2. <mods:originInfo>
  1. <mods:dateIssued encoding="iso8601">2020</mods:dateIssued>
  </mods:originInfo>
3. <mods:identifier type="issn">1662-4548</mods:identifier>
4. <mods:identifier type="doi">10.3389/fnins.2020.00107</mods:identifier>
5. <mods:identifier type="uri">https://academica-e.unavarra.es/handle/2454/37302</mods:identifier>
6. <mods:abstract>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</mods:abstract>
7. <mods:language>
  1. <mods:languageTerm>eng</mods:languageTerm>
  </mods:language>
8. <mods:accessCondition type="useAndReproduction">info:eu-repo/semantics/openAccess</mods:accessCondition>
9. <mods:accessCondition type="useAndReproduction">© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</mods:accessCondition>
10. <mods:subject>
  1. <mods:topic>Circadian</mods:topic>
  </mods:subject>
11. <mods:subject>
  1. <mods:topic>Peripheral clocks</mods:topic>
  </mods:subject>
12. <mods:subject>
  1. <mods:topic>Transcription factor</mods:topic>
  </mods:subject>
13. <mods:subject>
  1. <mods:topic>Light-dark cycles</mods:topic>
  </mods:subject>
14. <mods:subject>
  1. <mods:topic>Autonomous</mods:topic>
  </mods:subject>
15. <mods:titleInfo>
  1. <mods:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</mods:title>
  </mods:titleInfo>
16. <mods:genre>info:eu-repo/semantics/article</mods:genre>
</mods:mods>

oai_openaire

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<oaire:resource schemaLocation="http://namespace.openaire.eu/schema/oaire/ https://www.openaire.eu/schema/repo-lit/4.0/openaire.xsd">
1. <datacite:titles>
  1. <datacite:title lang="en">'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</datacite:title>
  </datacite:titles>
2. <datacite:creators>
  1. <datacite:creator>
    1. <datacite:creatorName nameType="Personal">Rotinen Díaz, Mirja Sofia</datacite:creatorName>
    2. <datacite:nameIdentifier nameIdentifierScheme="DSpace" schemeURI="http://dspace.org">/items/ecbb6fbe-3bda-4cad-945f-f263c1af5981</datacite:nameIdentifier>
    3. <datacite:nameIdentifier nameIdentifierScheme="DSpace" schemeURI="http://dspace.org">/items/ecbb6fbe-3bda-4cad-945f-f263c1af5981</datacite:nameIdentifier>
    </datacite:creator>
  </datacite:creators>
3. <datacite:contributors>
  1. <datacite:contributor>
    1. <datacite:contributorName>Ciencias de la Salud</datacite:contributorName>
    </datacite:contributor>
  2. <datacite:contributor>
    1. <datacite:contributorName>Osasun Zientziak</datacite:contributorName>
    </datacite:contributor>
  3. <datacite:contributor contributorType="HostingInstitution">
    1. <datacite:contributorName nameType="Organizational">Academica-e</datacite:contributorName>
    2. <datacite:nameIdentifier nameIdentifierScheme="e-mail" schemeURI="mailto:academica-e@unavarra.es">academica-e@unavarra.es</datacite:nameIdentifier>
    </datacite:contributor>
  </datacite:contributors>
4. <datacite:relatedIdentifiers>
  1. <datacite:relatedIdentifier relatedIdentifierType="ISSN" relationType="IsPartOf">1662-4548</datacite:relatedIdentifier>
  2. <datacite:relatedIdentifier relatedIdentifierType="DOI" relationType="IsPartOf">10.3389/fnins.2020.00107</datacite:relatedIdentifier>
  </datacite:relatedIdentifiers>
5. <datacite:dates>
  1. <datacite:date dateType="Accepted">2020</datacite:date>
  2. <datacite:date dateType="Issued">2020</datacite:date>
  </datacite:dates>
6. <dc:language>eng</dc:language>
7. <dc:publisher>Frontiers Media</dc:publisher>
8. <oaire:resourceType resourceTypeGeneral="literature" uri="http://purl.org/coar/resource_type/c_6501">journal article</oaire:resourceType>
9. <dc:description lang="en">These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</dc:description>
10. <dc:format>application/pdf</dc:format>
11. <datacite:identifier identifierType="URL">https://academica-e.unavarra.es/handle/2454/37302</datacite:identifier>
12. <datacite:rights rightsURI="http://purl.org/coar/access_right/c_abf2">open access</datacite:rights>
13. <datacite:subjects>
  1. <datacite:subject>Circadian</datacite:subject>
  2. <datacite:subject>Peripheral clocks</datacite:subject>
  3. <datacite:subject>Transcription factor</datacite:subject>
  4. <datacite:subject>Light-dark cycles</datacite:subject>
  5. <datacite:subject>Autonomous</datacite:subject>
  </datacite:subjects>
14. <datacite:sizes />
15. <datacite:sizes />
16. <datacite:sizes>
  1. <datacite:size>363013 bytes</datacite:size>
  </datacite:sizes>
17. <datacite:sizes />
18. <oaire:file accessRightsURI="http://purl.org/coar/access_right/c_abf2" mimeType="application/pdf" objectType="fulltext">https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download</oaire:file>
</oaire:resource>

ore

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<atom:entry schemaLocation="http://www.w3.org/2005/Atom http://www.kbcafe.com/rss/atom.xsd.xml">
1. <atom:id>https://academica-e.unavarra.es/handle/2454/37302/ore.xml</atom:id>
2. <atom:link href="https://academica-e.unavarra.es/handle/2454/37302" rel="alternate" />
3. <atom:link href="https://academica-e.unavarra.es/handle/2454/37302/ore.xml" rel="http://www.openarchives.org/ore/terms/describes" />
4. <atom:link href="https://academica-e.unavarra.es/handle/2454/37302/ore.xml#atom" rel="self" type="application/atom+xml" />
5. <atom:published />
6. <atom:updated />
7. <atom:source>
  1. <atom:generator>Academica-e</atom:generator>
  </atom:source>
8. <atom:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</atom:title>
9. <atom:author>
  1. <atom:name>Rotinen Díaz, Mirja Sofia</atom:name>
  </atom:author>
10. <atom:category label="Aggregation" scheme="http://www.openarchives.org/ore/terms/" term="http://www.openarchives.org/ore/terms/Aggregation" />
11. <atom:category scheme="http://www.openarchives.org/ore/atom/modified" term="" />
12. <atom:category label="DSpace Item" scheme="http://www.dspace.org/objectModel/" term="DSpaceItem" />
13. <atom:link href="https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download" length="363013" rel="http://www.openarchives.org/ore/terms/aggregates" title="2020060107_Rotinen_DefiningIndependence.pdf" type="application/pdf" />
14. <oreatom:triples>
  1. <rdf:Description about="https://academica-e.unavarra.es/handle/2454/37302/ore.xml#atom">
    1. <rdf:type resource="http://www.dspace.org/objectModel/DSpaceItem" />
    2. <dcterms:modified />
    </rdf:Description>
  2. <rdf:Description about="https://academica-e.unavarra.es/bitstreams/dd3a666b-e649-48ad-adf1-adf8ad28f915/download">
    1. <rdf:type resource="http://www.dspace.org/objectModel/DSpaceBitstream" />
    2. <dcterms:description>TEXT</dcterms:description>
    </rdf:Description>
  3. <rdf:Description about="https://academica-e.unavarra.es/bitstreams/72427489-feff-49b9-872a-6f0ee0d2b166/download">
    1. <rdf:type resource="http://www.dspace.org/objectModel/DSpaceBitstream" />
    2. <dcterms:description>THUMBNAIL</dcterms:description>
    </rdf:Description>
  4. <rdf:Description about="https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download">
    1. <rdf:type resource="http://www.dspace.org/objectModel/DSpaceBitstream" />
    2. <dcterms:description>ORIGINAL</dcterms:description>
    </rdf:Description>
  5. <rdf:Description about="https://academica-e.unavarra.es/bitstreams/1000ad27-3d31-4c90-ba90-b277d6a48355/download">
    1. <rdf:type resource="http://www.dspace.org/objectModel/DSpaceBitstream" />
    2. <dcterms:description>LICENSE</dcterms:description>
    </rdf:Description>
  </oreatom:triples>
</atom:entry>

qdc

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<qdc:qualifieddc schemaLocation="http://purl.org/dc/elements/1.1/ http://dublincore.org/schemas/xmls/qdc/2006/01/06/dc.xsd http://purl.org/dc/terms/ http://dublincore.org/schemas/xmls/qdc/2006/01/06/dcterms.xsd http://dspace.org/qualifieddc/ http://www.ukoln.ac.uk/metadata/dcmi/xmlschema/qualifieddc.xsd">
1. <dc:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</dc:title>
2. <dc:creator>Rotinen Díaz, Mirja Sofia</dc:creator>
3. <dc:contributor>Ciencias de la Salud</dc:contributor>
4. <dc:contributor>Osasun Zientziak</dc:contributor>
5. <dc:subject>Circadian</dc:subject>
6. <dc:subject>Peripheral clocks</dc:subject>
7. <dc:subject>Transcription factor</dc:subject>
8. <dc:subject>Light-dark cycles</dc:subject>
9. <dc:subject>Autonomous</dc:subject>
10. <dcterms:abstract>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</dcterms:abstract>
11. <dcterms:issued>2020</dcterms:issued>
12. <dc:type>info:eu-repo/semantics/article</dc:type>
13. <dc:identifier>1662-4548</dc:identifier>
14. <dc:identifier>10.3389/fnins.2020.00107</dc:identifier>
15. <dc:identifier>https://academica-e.unavarra.es/handle/2454/37302</dc:identifier>
16. <dc:language>eng</dc:language>
17. <dc:relation>Frontiers in Neuroscience, 2020, 14, 107</dc:relation>
18. <dc:relation>https://doi.org/10.3389/fnins.2020.00107</dc:relation>
19. <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
20. <dc:rights>© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</dc:rights>
21. <dc:publisher>Frontiers Media</dc:publisher>
</qdc:qualifieddc>

rdf

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<rdf:RDF schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
1. <ow:Publication about="oai:academica-e.unavarra.es:2454/37302">
  1. <dc:title>'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</dc:title>
  2. <dc:creator>Rotinen Díaz, Mirja Sofia</dc:creator>
  3. <dc:contributor>Ciencias de la Salud</dc:contributor>
  4. <dc:contributor>Osasun Zientziak</dc:contributor>
  5. <dc:subject>Circadian</dc:subject>
  6. <dc:subject>Peripheral clocks</dc:subject>
  7. <dc:subject>Transcription factor</dc:subject>
  8. <dc:subject>Light-dark cycles</dc:subject>
  9. <dc:subject>Autonomous</dc:subject>
  10. <dc:description>These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</dc:description>
  11. <dc:date>2020</dc:date>
  12. <dc:type>info:eu-repo/semantics/article</dc:type>
  13. <dc:identifier>1662-4548</dc:identifier>
  14. <dc:identifier>10.3389/fnins.2020.00107</dc:identifier>
  15. <dc:identifier>https://academica-e.unavarra.es/handle/2454/37302</dc:identifier>
  16. <dc:language>eng</dc:language>
  17. <dc:relation>Frontiers in Neuroscience, 2020, 14, 107</dc:relation>
  18. <dc:relation>https://doi.org/10.3389/fnins.2020.00107</dc:relation>
  19. <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  20. <dc:rights>© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</dc:rights>
  21. <dc:publisher>Frontiers Media</dc:publisher>
  </ow:Publication>
</rdf:RDF>

xoai

Deskargatu XML

<?xml version="1.0" encoding="UTF-8" ?>

<metadata schemaLocation="http://www.lyncode.com/xoai http://www.lyncode.com/xsd/xoai.xsd">
1. <element name="dspace">
  1. <element name="entity">
    1. <element name="type">
      1. <element name="none">
        <field name="value">Publication</field>
        </element>
      </element>
    </element>
  </element>
2. <element name="dc">
  1. <element name="contributor">
    1. <element name="author">
      1. <element name="none">
        <field name="value">Rotinen Díaz, Mirja Sofia</field>
        <field name="authority">virtual::14186</field>
        <field name="confidence">-1</field>
        </element>
      </element>
    2. <element name="department">
      1. <element name="es_ES">
        <field name="value">Ciencias de la Salud</field>
        </element>
      2. <element name="eu">
        <field name="value">Osasun Zientziak</field>
        </element>
      </element>
    </element>
  2. <element name="date">
    1. <element name="issued">
      1. <element name="none">
        <field name="value">2020</field>
        </element>
      </element>
    </element>
  3. <element name="identifier">
    1. <element name="issn">
      1. <element name="none">
        <field name="value">1662-4548</field>
        </element>
      </element>
    2. <element name="doi">
      1. <element name="none">
        <field name="value">10.3389/fnins.2020.00107</field>
        </element>
      </element>
    3. <element name="uri">
      1. <element name="none">
        <field name="value">https://academica-e.unavarra.es/handle/2454/37302</field>
        </element>
      </element>
    </element>
  4. <element name="description">
    1. <element name="abstract">
      1. <element name="en">
        <field name="value">These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ensure glucose homeostasis even if there is a glitch in the feedback system to the central clock (SCN). This could be of critical importance in environmentally challenging conditions to the organism. Our body needs to find a fine balance between diving into adjust its clocks in response to environmental stimuli and opposing change; otherwise we would live in a constant jet lag state. These studies provide evidence of the existence of at least two pathways regulating peripheral circadian clocks to reach that equilibrium. The first is an 'immediate and autonomous' response that allows organs to adjust to changes in light, without any input from other circadian clocks. The latter works as a 'fail safe copy' of past light regime that guarantees a certain degree of resistance and robustness to environmental changes, which is sustained by signals coming from other organs. Future studies will need to examine how the autonomous circadian clocks become deregulated in pathological contexts (obesity, metabolic disease, diabetes…).</field>
        </element>
      </element>
    2. <element name="sponsorship">
      1. <element name="en">
        <field name="value">This work was supported by The Spanish Ministry of Science, Innovation and Universities (Ramón y Cajal programme: RYC-2018-023874-I).</field>
        </element>
      </element>
    </element>
  5. <element name="format">
    1. <element name="extent">
      1. <element name="none">
        <field name="value">3 p.</field>
        </element>
      </element>
    2. <element name="mimetype">
      1. <element name="en">
        <field name="value">application/pdf</field>
        </element>
      </element>
    </element>
  6. <element name="language">
    1. <element name="iso">
      1. <element name="en">
        <field name="value">eng</field>
        </element>
      </element>
    </element>
  7. <element name="publisher">
    1. <element name="en">
      1. <field name="value">Frontiers Media</field>
      </element>
    </element>
  8. <element name="relation">
    1. <element name="ispartof">
      1. <element name="en">
        <field name="value">Frontiers in Neuroscience, 2020, 14, 107</field>
        </element>
      </element>
    2. <element name="publisherversion">
      1. <element name="none">
        <field name="value">https://doi.org/10.3389/fnins.2020.00107</field>
        </element>
      </element>
    </element>
  9. <element name="rights">
    1. <element name="en">
      1. <field name="value">© 2020 Rotinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</field>
      </element>
    2. <element name="accessRights">
      1. <element name="none">
        <field name="value">info:eu-repo/semantics/openAccess</field>
        </element>
      </element>
    </element>
  10. <element name="subject">
    1. <element name="en">
      1. <field name="value">Circadian</field>
      2. <field name="value">Peripheral clocks</field>
      3. <field name="value">Transcription factor</field>
      4. <field name="value">Light-dark cycles</field>
      5. <field name="value">Autonomous</field>
      </element>
    </element>
  11. <element name="title">
    1. <element name="en">
      1. <field name="value">'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis'</field>
      </element>
    </element>
  12. <element name="type">
    1. <element name="none">
      1. <field name="value">info:eu-repo/semantics/article</field>
      </element>
    2. <element name="version">
      1. <element name="en">
        <field name="value">info:eu-repo/semantics/publishedVersion</field>
        </element>
      2. <element name="es">
        <field name="value">Versión publicada / Argitaratu den bertsioa</field>
        </element>
      </element>
    </element>
  </element>
3. <element name="relation">
  1. <element name="isAuthorOfPublication">
    1. <element name="none">
      1. <field name="value">ecbb6fbe-3bda-4cad-945f-f263c1af5981</field>
      2. <field name="authority">virtual::14186</field>
      3. <field name="confidence">-1</field>
      </element>
    2. <element name="latestForDiscovery">
      1. <element name="none">
        <field name="value">ecbb6fbe-3bda-4cad-945f-f263c1af5981</field>
        <field name="authority">virtual::14186</field>
        <field name="confidence">-1</field>
        </element>
      </element>
    </element>
  </element>
4. <element name="bundles">
  1. <element name="bundle">
    1. <field name="name">TEXT</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">2020060107_Rotinen_DefiningIndependence.pdf.txt</field>
        <field name="originalName">2020060107_Rotinen_DefiningIndependence.pdf.txt</field>
        <field name="description">Extracted text</field>
        <field name="format">text/plain</field>
        <field name="size">12442</field>
        <field name="url">https://academica-e.unavarra.es/bitstreams/dd3a666b-e649-48ad-adf1-adf8ad28f915/download</field>
        <field name="checksum">c4a8a14519d97a7e1f69393ce3164d21</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">2</field>
        </element>
      </element>
    </element>
  2. <element name="bundle">
    1. <field name="name">THUMBNAIL</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">2020060107_Rotinen_DefiningIndependence.pdf.jpg</field>
        <field name="originalName">2020060107_Rotinen_DefiningIndependence.pdf.jpg</field>
        <field name="description">IM Thumbnail</field>
        <field name="format">image/jpeg</field>
        <field name="size">20784</field>
        <field name="url">https://academica-e.unavarra.es/bitstreams/72427489-feff-49b9-872a-6f0ee0d2b166/download</field>
        <field name="checksum">1b096519cd07e275557b7250ff25d2c0</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">3</field>
        </element>
      </element>
    </element>
  3. <element name="bundle">
    1. <field name="name">ORIGINAL</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">2020060107_Rotinen_DefiningIndependence.pdf</field>
        <field name="originalName">2020060107_Rotinen_DefiningIndependence.pdf</field>
        <field name="format">application/pdf</field>
        <field name="size">363013</field>
        <field name="url">https://academica-e.unavarra.es/bitstreams/9253fdd5-48e2-48c6-9ab3-96de604bf392/download</field>
        <field name="checksum">f99aaa28b8bce5b6eb585dc19ed42d35</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">1</field>
        </element>
      </element>
    </element>
  4. <element name="bundle">
    1. <field name="name">LICENSE</field>
    2. <element name="bitstreams">
      1. <element name="bitstream">
        <field name="name">license.txt</field>
        <field name="originalName">license.txt</field>
        <field name="format">text/plain; charset=utf-8</field>
        <field name="size">1748</field>
        <field name="url">https://academica-e.unavarra.es/bitstreams/1000ad27-3d31-4c90-ba90-b277d6a48355/download</field>
        <field name="checksum">bb9bdc0b3349e4284e09149f943790b4</field>
        <field name="checksumAlgorithm">MD5</field>
        <field name="sid">4</field>
        </element>
      </element>
    </element>
  </element>
5. <element name="others">
  1. <field name="handle">2454/37302</field>
  2. <field name="identifier">oai:academica-e.unavarra.es:2454/37302</field>
  3. <field name="lastModifyDate">2024-10-11 11:46:56.412</field>
  4. <element name="access-status">
    1. <field name="value">open.access</field>
    </element>
  </element>
6. <element name="repository">
  1. <field name="url">https://academica-e.unavarra.es</field>
  2. <field name="name">Academica-e</field>
  3. <field name="mail">academica-e@unavarra.es</field>
  </element>
7. <element name="license">
  1. <field name="bin">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</field>
  </element>
</metadata>