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A First-Stage Approximation to Identify New Imprinted Genes through Sequence Analysis of Its Coding Regions
Identificadores del recurso
978-84-7993-192-6
http://hdl.handle.net/10334/405
Procedencia
(Repositorio Institucional de la Universidad Internacional de Andalucía: UNIA)

Ficha

Título:
A First-Stage Approximation to Identify New Imprinted Genes through Sequence Analysis of Its Coding Regions
Tema:
Bioinformática
Biotecnología
Descripción:
Investigación dirigida por Antoni Romeu y Oswaldo Trelles. In the present study, a positive training set of 30 known human imprinted gene coding regions are compared with a set of 72 randomly sampled human nonimprinted gene coding regions (negative training set) to identify genomic features common to human imprinted genes. The most important feature of the present work is its ability to use multivariate analysis to look at variation, at coding region DNA level, among imprinted and non-imprinted genes. There is a force affecting genomic parameters that appears through the use of the appropriate multivariate methods (principle components analysis (PCA) and quadratic discriminant analysis (QDA)) to analyse quantitative genomic data. We show that variables, such as CG content, [bp]% CpG islands, [bp]% Large Tandem Repeats, and [bp]% Simple Repeats, are able to distinguish coding regions of human imprinted genes.
Idioma:
English
Relación:
III Máster en Bioinformática
Autor/Productor:
Daura Oller, Elias
Derechos:
Reconocimiento-NoComercial-SinObraDerivada 2.5 España
http://creativecommons.org/licenses/by-nc-nd/2.5/es/
openAccess
Fecha:
2010-04-21T09:35:42Z
2010
Tipo de recurso:
masterThesis

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            1. <field name="value">Investigación dirigida por Antoni Romeu y Oswaldo Trelles. In the present study, a positive training set of 30 known human imprinted gene coding regions are compared with a set of 72 randomly sampled human nonimprinted gene coding regions (negative training set) to identify genomic features common to human imprinted genes. The most important feature of the present work is its ability to use multivariate analysis to look at variation, at coding region DNA level, among imprinted and non-imprinted genes. There is a force affecting genomic parameters that appears through the use of the appropriate multivariate methods (principle components analysis (PCA) and quadratic discriminant analysis (QDA)) to analyse quantitative genomic data. We show that variables, such as CG content, [bp]% CpG islands, [bp]% Large Tandem Repeats, and [bp]% Simple Repeats, are able to distinguish coding regions of human imprinted genes.</field>

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