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3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer

Identificadores del recurso

Llinàs-Arias P, Ensenyat-Méndez M, Orozco JIJ, Íñiguez-Muñoz S, Valdez B, Wang C, et al. 3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer. BMC Genomic Data. 2023 Nov 2;24(1):61.

https://hdl.handle.net/20.500.13003/19967

10.1186/s12863-023-01166-x

2730-6844

37919672

L2026427195

2-s2.0-85175719906

001092189200001

Origin

(Docusalut. Repositorio institucional del sistema sanitario público de las Islas Baleares)

File

Title:: 3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer
Tema:: Triple Negative Breast Neoplasms; Breast; Chromatin; Gene Expression Profiling; Humans; Cell Line, Tumor; Línea Celular Tumoral; Humanos; Mama; Neoplasias de la Mama Triple Negativas; Cromatina; Perfilación de la Expresión Génica
Description:: Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Unlike other breast cancer subtypes, the scarcity of specific therapies and greater frequencies of distant metastases contribute to its aggressiveness. We aimed to find epigenetic changes that aid in the understanding of the dissemination process of these cancers. Using CRISPR/Cas9, our experimental approach led us to identify and disrupt an insulator element, IE8, whose activity seemed relevant for cell invasion. The experiments were performed in two well-established TNBC cellular models, the MDA-MB-231 and the MDA-MB-436. To gain insights into the underlying molecular mechanisms of TNBC invasion ability, we generated and characterized high-resolution chromatin interaction (Hi-C) and chromatin accessibility (ATAC-seq) maps in both cell models and complemented these datasets with gene expression profiling (RNA-seq) in MDA-MB-231, the cell line that showed more significant changes in chromatin accessibility. Altogether, our data provide a comprehensive resource for understanding the spatial organization of the genome in TNBC cells, which may contribute to accelerating the discovery of TNBC-specific alterations triggering advances for this devastating disease.
Idioma:: English
Relation:: https://doi.org/10.1186/s12863-023-01166-x
Autor/Productor:: Llinàs-Arias, Pere; Ensenyat-Mendez, Miquel; Orozco, Javier I J; Íñiguez-Muñoz, Sandra; Valdez, Betsy; Wang, Chuan; Mezger, Anja; Choi, Eunkyoung; Tran, Yan Zhou; Yao, Liqun; Bonath, Franziska; Olsen, Remi-André; Ormestad, Mattias; Esteller, Manel; Lupien, Mathieu; Marzese, Diego M
Publisher:: BMC
Rights:: Atribución 4.0 Internacional; http://creativecommons.org/licenses/by/4.0/; open access
Date:: 2023-11-15T07:37:23Z; 2023-11-02
Tipo de recurso:: research article

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