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<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
<dc:title>Single and longitudinal genome-wide association studies for dairy traits available in goats with three recorded lactations</dc:title>
<dc:creator>Luigi-Sierra, Maria Gracia</dc:creator>
<dc:creator>Martínez, Amparo</dc:creator>
<dc:creator>Macri, Martina</dc:creator>
<dc:creator>Delgado, Juan Vicente</dc:creator>
<dc:creator>Castelló, Anna</dc:creator>
<dc:creator>Fernández-Álvarez, Javier</dc:creator>
<dc:creator>Such, Xavier</dc:creator>
<dc:creator>Jordana, Jordi</dc:creator>
<dc:creator>Amills, Marcel</dc:creator>
<dc:contributor>Ministerio de Ciencia, Innovación y Universidades (España)</dc:contributor>
<dc:contributor>Agencia Estatal de Investigación (España)</dc:contributor>
<dc:contributor>European Commission</dc:contributor>
<dc:contributor>Generalitat de Catalunya</dc:contributor>
<dc:contributor>Ministerio de Economía y Competitividad (España)</dc:contributor>
<dc:contributor>Luigi-Sierra, Maria Gracia [0000-0002-6414-0550]</dc:contributor>
<dc:contributor>Castelló, Anna [0000-0001-8497-6251]</dc:contributor>
<dc:contributor>Amills, Marcel [0000-0002-8999-0770]</dc:contributor>
<dc:subject>GWAS</dc:subject>
<dc:subject>Milk yield and composition traits</dc:subject>
<dc:subject>Murciano-Granadina breed</dc:subject>
<dc:description>© 2023 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</dc:description>
<dc:description>Milk yield and composition phenotypes are systematically recorded across several lactations in goats, but the majority of genome-wide association studies (GWAS) performed so far have rather ignored the longitudinal nature of such data. Here, we have used two different GWAS approaches to analyse data from three lactations recorded in Murciano-Granadina goats. In Analysis 1, independent GWAS have been carried out for each trait and lactation, while a single longitudinal GWAS, jointly considering all data, has been performed in Analysis 2. In both analyses, genome-wide significant QTL for lactose percentage on chromosome 2 (129.77–131.01 Mb) and for milk protein percentage on the chromosome 6 (74.8–94.6 Mb) casein gene cluster region were detected. In Analysis 1, several QTL were not replicated in all three lactations, possibly due to the existence of lactation-specific genetic determinants. In Analysis 2, we identified several genome-wide significant QTL related to milk yield and protein content that were not uncovered in Analysis 1. The increased number of QTL identified in Analysis 2 suggests that the longitudinal GWAS is particularly well suited for the genetic analysis of dairy traits. Moreover, our data confirm that variability within or close to the casein complex is the main genetic determinant of milk protein percentage in Murciano-Granadina goats.</dc:description>
<dc:description>This research was funded by grant PID2019-105805RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by grant PID2022-136834OB-I00 funded by MCIIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. We also acknowledge the support of the CERCA Programme/Generalitat de Catalunya and of the Spanish Ministerio de Ciencia e Innovación for the Center of Excellence Severo Ochoa 2020–2023 (CEX2019–000902-S) grant awarded to the Centre for Research in Agricultural Genomics (CRAG, Bellaterra, Spain). Maria Luigi-Sierra was funded with a PhD fellowship Formación de Personal Investigador (BES-2017-079709) awarded by the Ministerio de Economía y Competitividad (Spain).</dc:description>
<dc:description>With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019–000902-S).</dc:description>
<dc:description>Peer reviewed</dc:description>
<dc:date>2024-04-24T15:58:17Z</dc:date>
<dc:date>2024-04-24T15:58:17Z</dc:date>
<dc:date>2024-04</dc:date>
<dc:type>artículo</dc:type>
<dc:identifier>Animal Genetics 55(2): 257-264 (2024)</dc:identifier>
<dc:identifier>0268-9146</dc:identifier>
<dc:identifier>CEX2019–000902-S</dc:identifier>
<dc:identifier>http://hdl.handle.net/10261/354892</dc:identifier>
<dc:identifier>10.1111/age.13391</dc:identifier>
<dc:identifier>1365-2052</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>#PLACEHOLDER_PARENT_METADATA_VALUE#</dc:relation>
<dc:relation>#PLACEHOLDER_PARENT_METADATA_VALUE#</dc:relation>
<dc:relation>#PLACEHOLDER_PARENT_METADATA_VALUE#</dc:relation>
<dc:relation>#PLACEHOLDER_PARENT_METADATA_VALUE#</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105805RB-I00/ES/UTILIZACION DE HERRAMIENTAS MASIVAS DE SECUENCIACION Y GENOTIPADO PARA EVALUAR EL IMPACTO DE LA VARIACION GENETICA SOBRE FENOTIPOS LECHEROS Y DE VIABILIDAD EN GANADO CAPRINO/</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136834OB-I00/ES/ANALISIS TRANSCRIPTOMICO DE LA LACTACION Y CARTOGRAFIADO FINO DE POLIMORFISMOS CON EFECTOS CAUSALES SOBRE FENOTIPOS LECHEROS Y DE VIABILIDAD EN LA RAZA MURCIANO-GRANADINA/</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/MINECO//BES-2017-079709</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/AEI//CEX2019-000902-S</dc:relation>
<dc:relation>Publisher's version</dc:relation>
<dc:relation>The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1111/age.13391</dc:relation>
<dc:relation>https://doi.org/10.1111/age.13391</dc:relation>
<dc:relation>Sí</dc:relation>
<dc:rights>open</dc:rights>
<dc:format>application/pdf</dc:format>
<dc:publisher>John Wiley & Sons</dc:publisher>
<dc:publisher>International Society for Animal Genetics</dc:publisher>
</oai_dc:dc>